frontiers1 : Atelier de travail pour le GPR Frontiers of Life

3-3 Feb 2020 Pessac (France)

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Day's schedule

Week Mon. 03 List

Monday, February 3, 2020

09:00

10:00

11:00

12:00

13:00

14:00

15:00

16:00

17:00

›9:00 (15min)

Welcome

9:00 - 9:15 (15min)

Welcome

loading of presentations

›9:15 (15min)

Introduction
JC Baret & V Gabelica

9:15 - 9:30 (15min)

Introduction

JC Baret & V Gabelica

›9:30 (40min)

Session A

9:30 - 10:10 (40min)

Session A

› Deciphering the antimicrobial resistance mechanisms and their dissemination: from fundamental to clinic aspects - Cécile Bébéar, Université de Bordeaux - Corinne Arpin, Université de Bordeaux 09:30-09:35 (05min)

› Structural and functional peculiarities in the cell-surface architecture and mRNA translation machineries in kinetoplastids - Yaser Hashem, Institut Européen de Chimie et Biologie, Acides Nucléiques : Régulations Naturelle et Artificielle 09:35-09:40 (05min)

› Controlling gene expression in a minimal cell - Fabien Darfeuille, Acides Nucléiques : Régulations Naturelles et Artificielles 09:40-09:45 (05min)

› Natural minimal cells, a blueprint for the construction of artificial cells - CAROLE LARTIGUE, UMR 1332-UB-INRAE 09:45-09:50 (05min)

›10:10 (40min)

Session B

10:10 - 10:50 (40min)

Session B

› Deciphering the metabolic dialogue of host-microbe communication - Frederic Bringaud, Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), CNRS UMR-5234 10:10-10:15 (05min)

› Characterizing the role, organization and compartmentalization of metabolic channels in ubiquitous central metabolic pathways - Arnaud Mourier, IBGC 10:15-10:20 (05min)

› Regulation of microbial infections by liquid-liquid-phase-separation (LLPS) - Vincent Parissi, Laboratoire de Microbiologie Fondamentale et Pathogénicité 10:20-10:25 (05min)

› Structural and functional characterization of disordered domains of microbial cellulases - Frederic Friscourt, Soutien à la Recherche de l'Institut Européen de Chimie Biologique, Institut de Neurosciences cognitives et intégratives d'Aquitaine 10:25-10:30 (05min)

›10:50 (30min)

coffee break

10:50 - 11:20 (30min)

coffee break

informal discussions

›11:20 (50min)

Session C

11:20 - 12:10 (50min)

Session C

› Cell-death mechanisms by a bacterial signalosome - Antoine Loquet, Chimie et Biologie des Membranes et des Nanoobjets 11:20-11:25 (05min)

› Photo‐switchable controlled release of RNA and DNA synthesis building blocks from minimal lipid-based vesicles: controlled reservoirs for RNA and DNA synthesis in artificial cells - Gilmar Salgado, Acides Nucléiques : Régulations Naturelle et Artificielle 11:25-11:30 (05min)

› Controlling inter-/intra-cellular communication, from passive to active transport through a synthetic vesicle membrane - Jeanne Leblond Chain, Régulations Naturelles et Artificielles 11:30-11:35 (05min)

› "Sturdy building blocks" for artificial cell constructs - Colin Bonduelle, Laboratoire de Chimie des Polymères Organiques (LCPO) 11:35-11:40 (05min)

› Out-of-equilibrium transport in Biology - Thomas Guerin, Laboratoire Ondes et Matière d'Aquitaine (LOMA) 11:40-11:45 (05min)

›12:10 (30min)

Session D

12:10 - 12:40 (30min)

Session D

› Generation of self-sustained chimeric membranes allowing functional activity of membranous proteins - Claire Brehelin, Laboratoire de Biogenèse Membranaire - LBM (Bordeaux, France) 12:10-12:15 (05min)

› MECHSYN : Mechanics and physical models of the synthetic cell - Ulysse Delabre, Laboratoire Ondes et Matière dÁquitaine, Unité de Formation de Physique 12:15-12:20 (05min)

› Multiscale and multimodal experimental and numerical approaches to correlate at molecular, cellular and tissular levels the structural, chemical and functional properties of the different objects studied in Frontiers of Life. - Michael Molinari, Chimie et Biologie des Membranes et des Nanoobjets 12:20-12:25 (05min)

›12:40 (1h10)

Lunch

12:40 - 13:50 (1h10)

Lunch

›13:50 (30min)

Session E

13:50 - 14:20 (30min)

Session E

› Designing compartments from water-in-water emulsions as artificial cells - J-Paul Douliez, Biologie du fruit et pathologie 13:50-13:55 (05min)

› Reconstituting membraneless liquid-liquid phase-separated condensates based on RNA systems - Cameron Mackereth, ARNA 13:55-14:00 (05min)

› Development of hybrid cells by integrating biological organelles to synthetic cells - Stéphane Arbault, Univ. Bordeaux, ISM, CNRS UMR 5255, NSysA group, ENSCBP, 33607, Pessac, France 14:00-14:05 (05min)

›14:20 (30min)

Session F

14:20 - 14:50 (30min)

Session F

› Making compartments inside a living cell in a controllable way using RNA self-assembly - Juan Elezgaray, Chimie et Biologie des Membranes et des Nanoobjets 14:20-14:25 (05min)

› Reactivity in confined environments and at soft interfaces: towards self-sustained synthetic cells? - Nicolas Martin, Centre de Recherche Paul Pascal - Valérie Desvergnes, Régulations Naturelles et Artificielles 14:25-14:30 (05min)

› Biocompatible motility and mobility mechanisms of protocells: toward a self-propelled synthetic cell. - Eric Grelet, Centre de Recherche Paul Pascal 14:30-14:35 (05min)

›14:50 (40min)

coffee break

14:50 - 15:30 (40min)

coffee break

informal discussions

›15:30 (30min)

Session G

15:30 - 16:00 (30min)

Session G

› Understanding the role of soft synthetic smart materials on cell fate and behaviors - Philippe Barthélémy, Régulations Naturelles et Artificielles 15:30-15:35 (05min)

› Strategies to develop stem cell recruiting bioactive materials for tissue repair and regeneration - Marie-Christine Durrieu, Chimie & Biologie des Membranes et des Nano-objets - Institut Européen de Chimie et Biologie 15:35-15:40 (05min)

› Stem cells on board towards regenerative medicine - Hélène Boeuf, Inserm U1026 15:40-15:45 (05min)

› Cell communication in physiological and repairing bone tissue. - Delphine Maurel, U1026 Biotis 15:45-15:50 (05min)

›16:00 (40min)

Session H

16:00 - 16:40 (40min)

Session H

› Multiscale vascularisation of engineered tissues: an interdisciplinary approach to assemble functional and implantable grafts - Gaelle Recher, Laboratoire Photonique, Numérique et Nanosciences 16:00-16:05 (05min)

› Mechanics and rheology of biomaterials - Jean-Pierre Delville, Laboratoire Ondes et Matière d'Aquitaine 16:05-16:10 (05min)

› An alternative human pathology model to animal models: Organs-On-Chips (OOC) - Karine Dementhon, Université de Bordeaux, Laboratoire Microbiologie Fondamentale et Pathogénicité - Pierre Nassoy, Laboratoire Photonique, Numérique et Nanosciences 16:10-16:15 (05min)

› Proof of concept of innovations in life sciences for validation before transfer to the clinics - Marlene Durand, CIC IT, Bioingénierie tissulaire 16:15-16:20 (05min)

›16:40 (20min)

closing discussion

16:40 - 17:00 (20min)

closing discussion

summary and outline of action plan

Session

Speech

Logistics

Break

Tour

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